Metastasis of Uveal Melanoma in Bladder: Presentation of Two Cases and Review of the Literature

Objective: Secondary urinary bladder tumors account for 2% of neoplasms in this location. Melanoma is the neoplasm that mostfrequently produces distant metastases in the bladder. Despite its low prevalence, it should be a possible diagnosis to considerfacing urological symptoms, due to the existence of targeted therapies. Method: We present two cases of uveal melanoma metastasis in the bladder, their characteristics, and a review of the literature. Result: In this paper we present the histological characteristics and complementary techniques for the diagnosis of bladder metastases of melanoma and propose their inclusion among the possible differential diagnoses for bladder neoplasms. Conclusions: Given that there are currently targeted therapies against melanoma, the relevance of their inclusion in the differential diagnosis of bladder tumors stands out. (AU)

Objetivo: La vejiga urinaria no es un órgano frecuente de metastasis a distancia. Sin embargo, se puedever afectada secundariamente en un 2% de todas las neoplasias. Dicha afectación se produce habitualmente por extensión local de otros tumores, aunque, ciertas neoplasias pueden producir metástasis a distancia en la vejiga, como es el caso del melanoma. A pesar de esta baja prevalencia, los antecedentes personales del paciente deben ser tenido sen cuenta en el diagnóstico de la neoplasia vesical. Método: Se presentan dos casos de metástasis de melanoma uveal en vejiga, sus características y una revisiónde la literatura.Resultado: En este trabajo se exponen las características histológicas y las técnicas complementarias para el diagnóstico de las metástasis de melanoma y se resalta su importancia en el diagnóstico de las neoplasias vesicales. Conclusiones: Dado que actualmente existen terapiasdirigidas frente al melanoma, se destaca la relevancia de suinclusión en el diagnóstico diferencial de los tumores de lavejiga. (AU)

Metastasis of Uveal Melanoma in Bladder: Presentation of Two Cases and Review of the Literature.

OBJECTIVE: Secondary urinary bladder tumors account for 2% of neoplasms in this location. Melanoma is the neoplasm that most frequently produces distant metastases in the bladder. Despite its low prevalence, it should be a possible diagnosis to consider facing urological symptoms, due to the existence of targeted therapies. METHOD: We present two cases of uveal melanoma metastasis in the bladder, their characteristics, and a review of the literature. RESULT: In this paper we present the histological characteristics and complementary techniques for the diagnosis of bladder metastases of melanoma and propose their inclusion among the possible differential diagnoses for bladder neoplasms. CONCLUSIONS: Given that there are currently targeted therapies against melanoma, the relevance of their inclusion in the differential diagnosis of bladder tumors stands out.

Sarcoma sinovial bifásico pulmonar: presentación de un caso y revisión de la literatura / Biphasic synovial sarcoma of the lung: report of a case and review of the literature

Introduction: Synovial sarcoma is an aggressive neoplasm described in several locations but is uncommon in the lung. Method: We report a case of biphasic synovial sarcoma of the lung stressing the histologic and immunohistochemical characteristics, genetics and differential diagnosis. Results: a biphasic pattern and SYT-SSX translocation were demostrated. Comments: histology and immuno-histochemistry lead to diagnosis most of the times but the typical translocation is definitive.

Introducción: El sarcoma sinovial es una neoplasia agresiva que aun habiendo sido descrita en múltiples localizaciones, resulta sumamente infrecuente en localización pulmonar. Método: Presentamos un caso de sarcoma sinovial bifásico de localización pulmonar haciendo hincapié en sus características histológicas inmunohistoquímicas y genéticas así como en su diagnóstico diferencial. Resultados: La neoplasia mostraba un patrón bifásico bien caracterizado. El estudio genético demostró la translocación SYT-SSX. Comentarios: Si bien la histología y la inmunohistoquímica permiten en la mayoría de los casos el diagnóstico del sarcoma sinovial, es la translocación genética la que define verdaderamente esta entidad.

[Ureteral endometriosis. Case report]. / Endometriosis ureteral. A propósito de un caso.

OBJECTIVES: Ureteral endometriosis is a rare entity which may produce urinary tract obstruction with subsequent loss of renal function if treatment is not undertaken early due to its asymptomatic but locally aggressive course. METHODS/RESULTS: We report one case of intrinsic ureteral endometriosis with unilateral renal failure (renal atrophy) and unresectable periureteral fibroinflammatory thickening involving vascular or visceral structures. CONCLUSIONS: We emphasize the diagnostic and therapeutic importance of a high degree of clinical suspicion about this entity, mainly in patients with history of genital endometriosis.

Endometriosis ureteral. A propósito de un caso / Ureteral endometriosis. Case report

OBJETIVOS: La endometriosis ureteral es una entidad poco frecuente que debido a su curso asintomáticopero a la vez localmente agresivo puede originar un cuadro de obstrucción urinaria con la subsiguiente pérdida de la función renal si no se instaura un tratamiento precozmente.MÉTODO/RESULTADOS: Presentamos un caso de endometriosisureteral intrínseca acompañado de insuficiencia renal unilateral (atrofia renal) y plastrón fibroinflamatorio periureteral irresecable al englobar estructuras vasculares y viscerales.CONCLUSIONES: Destacamos la importancia diagnósticay terapéutica que conlleva un alto índice de sospecha clínica de esta entidad sobre todo en aquellas pacientes con antecedentes de endometriosis genital

OBJECTIVES: Ureteral endometriosis is a rare entity which may produce urinary tract obstruction with subsequent loss of renal function if treatment is not undertaken ;;early due to its asymptomatic but locally aggressive course. ;;METHODS/RESULTS: We report one case of intrinsic ureteral endometriosis with unilateral renal failure (renal atrophy) and unresectable periureteral fibroinflammatory thickening involving vascular or visceral structures. ;;CONCLUSIONS: We emphasize the diagnostic and ;;therapeutic importance of a high degree of clinical suspicion about this entity, mainly in patients with history of genital endometriosis

Myofibrosarcoma (low-grade myofibroblastic sarcoma) with intracytoplasmic hyaline (fibroma-like) inclusion bodies.

Myofibrosarcoma is a controversial neoplasm composed of cells with differentiation toward myofibroblasts. The authors report an unusual case of myofibrosarcoma in which, in addition to the characteristic features reported, tumor cells contained intracytoplasmic hyaline (fibroma-like) inclusion bodies. A 66-year-old man complained of a painless enlarged mass in his right shoulder over the previous 6 months. The tumor recurred 2 years after operation. On histologic examination, the tumor displayed diffusely infiltrative growth with isolation of individual skeletal muscle fibers. The tumor cells were most often arranged in an intersecting (herringbone) fascicular pattern but a vaguely storiform pattern was also observed. Cellularity varied from one area to another. The cells were spindle-shaped, with ill-define pale eosinophilic cytoplasm, and a wavy or tapering nucleus with fine chromatin and small nucleoli. Intracytoplasmic hyaline inclusion bodies of variable size, often located adjacent to the nucleus, were visible in numerous spindle and stellate cells. The mitotic index was 3/10 HPF. The tumor was scored as grade 1. Immunohistochemistry revealed positive staining to muscle-specific actin, desmin and vimentin in most tumor cells. Intracytoplasmic hyaline inclusion bodies did not react specifically to any one antibody, but showed a marked ring-like immune reaction, particularly to muscle-specific actin. Electron microscopy showed tumor cells with indented nuclei and small nucleoli, abundant rough endoplasmic reticulum, micropinocytotic vesicles, and longitudinally arranged fine filaments with focal electron-dense patches and subplasmalemmal plaques. The most striking feature was the presence of large, globular or ball-like, non-membrane-bound, randomly scattered clusters of fine filament, usually adjacent to the nucleus.